Postdoc position: Genome engineered HSCs to improve bone marrow transplantation, 100%

We are seeking a highly motivated postdoc to join our growing team at the Department of Biomedicine (DBM) in Basel, Switzerland. This ERC-funded project explores alternative approaches to conventional "bone marrow transplantation". We use genome engineered hematopoietic stem cells (HSC) to increase safety and efficacy of HSC transplants. The successful candidate will be a key member of the team that establishes and works with humanized mouse models to investigate genome engineered human HSCs in vivo. An established, highly interactive collaboration with a biotech startup will allow us to translate our research to clinical products.

Your position

• Genome engineer human HSCs (and human T cells) using state-of-the art techniques such as CRISPR/Cas and base editing
• Establish hHSC transplantation into NSG-SGM3 mice. Use this model to monitor engraftment and differentiation of engineered human hematopoietic cells in vivo
• Compare different cell depleting modalities in vivo: mAb, ADC, T cell engager, CAR T
• Multiparameter Flow Cytometry (Fortessa, Aurora, CyTOF available)
• Multiparameter histology (CODEX or CyTOF/Hyperion)

Your profile

• Experience in working with primary human cells, preferably HSCs and/or T cells
• Strong immunology background
• Extensive expertise with multicolor FACS and/or multiparameter histology
• Hands-on experience working with mice is required, practice in handling humanized mice a plus
• Genome engineering experience is a plus but not required
• Independent driver of project but also enjoys working in dynamic, interdisciplinary team (work with bioinformaticians, cell/genome engineers, protein engineers)
• Interest in multicolor histology required if no prior experience
• Flexible mindset with a strong "can do" attitude paired with attention to detail
• Good English knowledge (spoken and written); German not necessary but a plus

We offer you

• Working in an international, multidisciplinary team
• Unique opportunity to establish and work on mouse models with a direct translational impact
• Ongoing academic collaborations with global leaders in the field of hHSC engineering
• Key member of a team addressing a challenging goal. Highly interdisciplinary project in collaboration with industry partner that provides synergistic knowhow and resources
• Salary and compensation according to the guidelines of the University Hospital Basel

Application / Contact

Please send applications with CV, a description of relevant experience and the names of 3 referees to Nicole Salvisberg by email: nicole.salvisberg@unibas.ch. The position is available immediately or upon agreement. For informal inquiries please contact Prof. Lukas Jeker (lukas.jeker@unibas.ch).

University of Basel

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