Postdoctoral Researcher Transcription and DNA Replication
Do you have a fascination for understanding how the human genome operates? We are currently seeking a postdoc to delve into the molecular mechanisms at the crossroads of gene transcription and DNA replication in human cells.
About your role
Transcription and replication are essential cellular processes that maintain cell identity and ensure the faithful transmission of genetic information. Since transcription and replication share the same template DNA, their coexistence in the genome must be tightly coordinated to prevent harmful conflicts. Research in the Luijsterburg lab focuses on understanding how cells deal with obstacles during gene transcription (Van der Weegen et al., 2021, Nat Cell Biol; Van der Heuvel et al., Nat Comms, 2021). Through genome-wide CRISPR screens, we have uncovered new pathways involved in enabling cells to fine-tune the coordination of gene transcription and DNA replication to minimize transcription-replication collision and ensure genome integrity. In the current project, funded by an NWO-VICI grant, you will dissect these pathways using a multidisciplinary combination of genetic, molecular, cell biological, and complementary genomics approaches to unravel new mechanisms at the intersection of gene transcription and DNA replication.
About you
Our offer
Getting better by breaking new ground; that's our mission. This applies not only to healthcare, but also to our employees. In order to be able to continue to learn and develop, we offer internal and external training. You are also entitled to an end-of-year bonus (8,3%), holiday allowance, sports budget and bicycle scheme. Furthermore, as an employee of LUMC, you are also affiliated with the ABP pension fund. This means that 70% of your pension premium is paid by LUMC, leaving you with a higher net salary.
See all employment conditions of the LUMC.
About your workplace
You will work in the Human Genetics (HG) department of the LUMC, which comprises 22 research groups. The HG department is broadly oriented with a particular emphasis on the genetic contribution to human disease. You will be part of the ‘Transcription and DNA Repair’ group led by Dr. M.S. Luijsterburg, situated within the 'Genetic Instability and Cancer' cluster. This cluster aims to elucidate the cellular response to different DNA-damaging agents and its relevance for human health, focusing on the mechanisms underlying DNA repair and mutagenesis. The expertise and technical facilities of these DNA repair research groups are highly complementary, creating a collaborative environment for cutting-edge research in the DNA repair field. Outstanding facilities for advanced live-cell imaging, genetic screening, and interaction proteomics are available. The Luijsterburg group holds a strong national and international position, collaborating with academic partners across Europe and the US. Additionally, the group has strong connections with patient organizations focusing on DNA repair-deficiency syndromes.
What do we represent?
Our health is our greatest asset. Unlike any other profession, in healthcare, you can fully appreciate the entire spectrum of humanity in all its breadth. LUMC, as an academic medical center, wholeheartedly embraces that diversity! We strive for the highest quality in healthcare, education, and (international) research. We aim to be a creative and inspiring workplace. It is essential that everyone feels at home, safe, and recognized. That is why the LUMC was the first academic medical center to partner with Workplace Pride. Our active network, LUMC Pride, is dedicated to optimal inclusivity and diversity within our organization. Regardless of origin, gender, appearance, age, identity, orientation, or faith, you are a valuable part of our organization. Together, we are LUMC.
More information
Links
Contact
Dr. Martijn S. Luijsterburg, associate professor, department of Human Genetics
Tel. 071 526 96 12
Academic Europe, the European career network for Academics, Researchers and Scientists
