PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments
100%, starting July (negotiable)
The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student with a background in (bio-)physics, or biophysical chemistry to join our team for the study of allosteric mechanisms governing recently discovered CRISPR associated proteins using novel techniques, such as single-molecule fluorescence/FRET and nanopore trapping.
Your position
This PhD project will grow with you. You will create time-resolved direct observations of single CARF proteins – aka. CRISPR suicide proteins – undergoing allosteric activation, substrate processing, deactivation, etc. How this works, on what timescales, by which conformational rearrangements has not been observed yet in real-time, leaving the underlying molecular processes obscure. In this PhD project, you'll be able to solve (some of) these nanoscale puzzles. Steps involved in the project:
Your profile
Prior experience in several of these areas is desired:
Essential requirements:
We offer you
Application / Contact
Applications are invited before/by April 30th, 2024. Please submit your application via sonja.schmid@unibas.ch with subject 'Application PhD4 Firstname Lastname', and include:
your letter of motivation, your CV, and email addresses of 2-3 references – all merged into one single pdf file named 'Application PhD4 Firstname Lastname.pdf'.
For questions, please contact Prof. Sonja Schmid: sonja.schmid@unibas.ch.
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